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Ritva Tikkanen Selected Research

Aspartylglucosylaminase (Aspartylglucosaminidase)

1/2021Pre-clinical Gene Therapy with AAV9/AGA in Aspartylglucosaminuria Mice Provides Evidence for Clinical Translation.
3/2018Amlexanox provides a potential therapy for nonsense mutations in the lysosomal storage disorder Aspartylglucosaminuria.
11/2016Identification of Small Molecule Compounds for Pharmacological Chaperone Therapy of Aspartylglucosaminuria.

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Ritva Tikkanen Research Topics

Disease

7Neoplasms (Cancer)
01/2019 - 01/2012
5Pemphigus (Pemphigus Vulgaris)
10/2022 - 01/2016
5Aspartylglucosaminuria
10/2021 - 11/2016
4Neoplasm Metastasis (Metastasis)
04/2018 - 02/2014
3Breast Neoplasms (Breast Cancer)
02/2014 - 01/2013
2Blister (Bulla)
10/2022 - 06/2019
2Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis)
10/2021 - 02/2018
2Inborn Genetic Diseases (Disease, Hereditary)
10/2021 - 01/2020
2Infections
01/2021 - 01/2019
2succinic semialdehyde dehydrogenase deficiency
11/2020 - 01/2020
2Inflammation (Inflammations)
01/2019 - 08/2008
2Alzheimer Disease (Alzheimer's Disease)
04/2014 - 03/2007
1Multiple Myeloma
01/2022
1Acantholysis
01/2022
1Hypoxia (Hypoxemia)
01/2022
1Lysosomal Storage Diseases (Lysosomal Storage Disease)
01/2021
1Autoimmune Diseases (Autoimmune Disease)
06/2019
1Hypertrophy
01/2019
1Fibrosis (Cirrhosis)
01/2019
1Intellectual Disability (Idiocy)
03/2018
1Adenocarcinoma
12/2013
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2012
1Glomerulonephritis
08/2008
1Autosomal Dominant Polycystic Kidney (ADPKD)
11/2005

Drug/Important Bio-Agent (IBA)

10flotillinsIBA
06/2019 - 01/2012
6Proteins (Proteins, Gene)FDA Link
10/2022 - 11/2005
4AntibodiesIBA
10/2022 - 06/2019
4EnzymesIBA
10/2021 - 11/2016
3AutoantibodiesIBA
10/2022 - 01/2016
3Aspartylglucosylaminase (Aspartylglucosaminidase)IBA
01/2021 - 11/2016
2Immunoglobulin G (IgG)IBA
10/2022 - 01/2022
2DesmogleinsIBA
10/2022 - 01/2022
2dispaseIBA
01/2022 - 06/2019
2Messenger RNA (mRNA)IBA
01/2022 - 10/2021
2Butyric Acid (Butanoic Acid)IBA
11/2020 - 01/2020
2Neurotransmitter Agents (Neurotransmitter)IBA
11/2020 - 01/2020
2gamma-Aminobutyric Acid (GABA)IBA
11/2020 - 01/2020
2Amyloid (Amyloid Fibrils)IBA
04/2014 - 03/2007
1neonatal Fc receptorIBA
10/2022
1Immunoglobulin Fc FragmentsIBA
10/2022
1asparaginylendopeptidase (legumain)IBA
01/2022
1Cysteine Proteases (Cysteine Protease)IBA
01/2022
1DesmocollinsIBA
01/2022
1ProteomeIBA
01/2022
1Oxygen (Dioxygen)IBA
01/2022
1FlavonoidsIBA
10/2021
1methylxanthineIBA
10/2021
1LuteolinIBA
10/2021
1N-Acetylneuraminic Acid (Sialic Acid)IBA
01/2021
1IronIBA
09/2020
1CalciumIBA
06/2019
1Desmosomal CadherinsIBA
06/2019
1Detergents (Detergent)IBA
06/2019
1Cadherins (E-Cadherin)IBA
01/2019
1CytokinesIBA
01/2019
1amlexanox (Aphthasol)FDA Link
03/2018
1Nonsense Codon (Nonsense Mutation)IBA
03/2018
1GangliosidesIBA
02/2018
1G(M3) GangliosideIBA
02/2018
1Glycoproteins (Glycoprotein)IBA
11/2016
1Mutant Proteins (Protein, Mutant)IBA
08/2014
1Sorafenib (BAY 43-9006)FDA Link
08/2014
1Mitogen-Activated Protein KinasesIBA
08/2014
1Phosphotransferases (Kinase)IBA
08/2014
12- (4- (1- (hydroxyimino)- 2,3- dihydro- 1H- inden- 5- yl)- 3- (pyridin- 4- yl)- 1H- pyrazol- 1- yl)ethan- 1- olIBA
08/2014
1Mitogen-Activated Protein Kinase 3IBA
08/2014
1MAP Kinase Kinase 1IBA
08/2014
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
04/2014
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
02/2014
1ErbB Receptors (EGF Receptor)IBA
12/2013
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
12/2013
1Chemokine CXCL16IBA
08/2008
1Peptides (Polypeptides)IBA
03/2007
1TRPP Cation ChannelsIBA
11/2005

Therapy/Procedure

7Therapeutics
10/2021 - 12/2013